Manufacturing
How does one manufacture any given therapeutic modality? Here we summarize the standard technologies and the innovations shaping the market.
An introduction to the manufacturing of any given modality, including the technology underpinning the critical steps. We cover both upstream and downstream processes for drug substance manufacturing in mammalian systems such as CHO, viral vectors, microbial systems such as E. coli, cell therapies, mRNA, and pDNA. We also survey the technologies for oral solid dose, including different granulation methods, spray-drying, hot melt extrusion, and manufacture of pills and capsules.
