Overlooked Molecular Machine in Cell Nucleus May Hold Key to Treating Aggressive Leukemia

Spliceosome Misconnects Generate Mutant Gene/Protein that Fuel Cancerous Cells

CINCINNATI /PRNewswire/ -- Many individuals forced to fight an exceptionally aggressive form of the blood cancer acute myeloid leukemia (AML) don't survive more than five years.

The only cure—a bone marrow transplant—often isn't suitable for these very sick patients. Now, an international team of scientists report in Nature Cell Biology on a long-overlooked part of a leukemic cell's internal machinery called the spliceosome, where they found a hyperactive form of a protein called IRAK4 that sends cells on a cancer-causing frenzy.

 

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