1.1.1 Plasmids have long been the workhorse of the biotechnology industry, but because of the enormous requirements of plasmid DNA (pDNA) for production of viral vectors and other advanced therapies, they have only recently come to the forefront as a manufacturing challenge. Advanced therapies are the main driver for plasmid DNA production at large scale.
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1.2.1 The term “plasmid” was coined in 1952 by Joshua Lederberg[6] as a term to denote extrachromosomal genetic material in E. coli and Salmonella species. At the time, there was much effort to distinguish this “filterable agent” that could transduce genetic material from bacteriophage, which were also known to transfer genetic material between bacteria.[6][7] His work identifying a non-phage, nonchromosomal genetic element that could transfer between bacteria was published less than a decade after Avery, MacLeod, and McCarty demonstrated that DNA is the genetic material by using and a year before Watson and Crick proposed the structure of DNA.
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1.3.1 In early 2024, we received many questions regarding the funding outlook for biotech. The following is our answer to these questions. While the text was also published on Pharma’s Almanac under the title “Biotech Funding Ups and Downs” in April 2024,[14] we are reproducing it here for the convenience of our readers. The following sections update the history lesson for the 2024 outlook.
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1.4.1 So where do we stand, and what is the outlook for 2024? Analysts consider the bottleneck to be pharma acquisitions, so this is where we must look for forecasting the return of capital to the biotech markets. Although a few large exits, notably in the ADC space, have made news,[27][28][29] exit activity as of Q2 2024 is still depressed. PitchBook reported $14.5B in exits over 39 deals. When compared to the 2023 total ($20B over 97 deals) this indicates the value of the ongoing deals, at least is on the rise, even if the total number of exits is not.
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1.5.1 The pharmaceutical industry, once buoyed by the unprecedented demand and rapid innovation triggered by the COVID-19 pandemic, is currently readjusting to a post-COVID world, which has brought its own challenges, including a wave of layoffs that has swept across the biotech and pharma landscape in the past few years. This undercurrent of job reductions and corporate restructuring echoes the industry’s reflex to recalibrate in response to market pressures and strategic realignments, which appears at odds with forecasts of robust drug sales and potential market growth.
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